Goodpasture's disease.
نویسندگان
چکیده
Goodpasture’s disease (also known as Goodpasture syndrome, anti-glomerular basement membrane disease, anti-GBM disease) is an uncommon yet well known condition because of the striking way in which it can cause rapid destruction of the kidneys and bleeding into the lungs. A patient with this syndrome was first described by Ernest Goodpasture in 1919. However, it is now known that several diseases can cause a similar presentation. Goodpasture’s name is most usefully reserved for those with anti-GBM disease.
منابع مشابه
Goodpasture's disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis.
PURPOSE OF REVIEW Goodpasture's disease is an autoimmune disorder characterized by the deposition of pathogenic autoantibodies in basement membranes of kidney and lung, which induces rapidly progressive glomerulonephritis and pulmonary hemorrhage. The target antigen is the α3NC1 domain of collagen IV, which is expressed in target organs as an α345 network. Recent studies of specificity and epit...
متن کاملImaging Findings of Central Nervous System Vasculitis Associated with Goodpasture's Syndrome: a Case Report
Glomerulonephritis and pulmonary hemorrhage are features of Goodpasture's syndrome. Goodpasture's syndrome accompanied with central nervous system (CNS) vasculitis is extremely rare. Herein, we report a rare case of CNS vasculitis associated with Goodpasture's syndrome in a 34-year-old man, who presented with a seizure and sudden onset of right sided weakness. He also had recurrent hemoptysis o...
متن کاملMolecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.
BACKGROUND In Goodpasture's disease, circulating autoantibodies bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GBM). The specificity and molecular architecture of epitopes of tissue-bound autoantibodies are unknown. Alport's post-transplantation nephritis, which is mediated by alloantibodies against the GBM, occurs after kidney transplantation...
متن کاملRenal vein thrombosis. Initial manifestation of Goodpasture's syndrome.
We report a patient who presented with renal vein thrombosis and nephrosis that progressed to alveolar hemorrhage and renal failure. Renal biopsy immunofluorescence and serum antiglomerular basement membrane antibody titer studies confirmed the diagnosis of Goodpasture's syndrome. To our knowledge, this is the first report of renal vein thrombosis as the initial presentation of Goodpasture's sy...
متن کاملSevere Relapsing Goodpasture's Disease Successfully Treated with Mycophenolate Mofetil
Goodpasture's disease is a rare autoimmune disorder characterised by the development of antiglomerular basement membrane autoantibodies, which typically presents with rapidly progressive crescentic glomerulonephritis and pulmonary haemorrhage. Even with aggressive nonspecific immunosuppression and plasma exchange, mortality remains high. We report a case of life-threatening Goodpasture's diseas...
متن کاملCerebral involvement in a patient with Goodpasture's disease due to shortened induction therapy: a case report
INTRODUCTION Goodpasture's disease is a rare immunological disease with formation of pathognomonic antibodies against renal and pulmonary basement membranes. Cerebral involvement has been reported in several cases in the literature, yet the pathogenetic mechanism is not entirely clear. CASE PRESENTATION A 21-year-old Caucasian man with Goodpasture's disease and end-stage renal disease present...
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عنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 16 Suppl 6 شماره
صفحات -
تاریخ انتشار 2001